Experimental Medicine and Advanced Therapies Unit
Experimental prevention and treatment therapies in preclinical models, which lay the foundations for clinical studies of patients with metabolic disease and obesity.
What does this unit do?
In this unit, we develop novel therapies of synthetic molecules, natural products, immunomodulatory strategies, cellular and molecular therapy, and controlled release systems, which can generate proofs-of-concept and personalized treatments (drugs) for metabolic diseases.
Experimental medicine
Experimental medicine refers to deciphering the pathophysiological mechanisms of various diseases, identifying new therapeutic targets, and contributing to developing new drugs.
Although experimental medicine is widely developed with different approaches in Mexico, as in many countries worldwide, translating its major advances into cutting-edge and direct clinical applications is a constant challenge. Few groups in our country have achieved such transfer. Tecnologico de Monterrey has some successful examples in the transfer of experimental medicine, which has allowed the institution to lay the foundation to improve the coordination of efforts and transfer results from the laboratory to clinical practice.
Design of new drugs
In the context of obesity, some comorbidities such as hypertension, diabetes, and fatty liver require developing new drugs that reduce morbidity and mortality.
There is currently no ideal treatment for obesity and its comorbidities; for this reason, our health system seeks a new route for prevention and treatment with new drugs and innovative therapies that are more effective, specific, and with less risk of side effects.
Meet the researchers
Dr. Gerardo de Jesús García Rivas
Leader of the Experimental Medicine and Advanced Therapies Unit
Biochemistry, Biology, Biological Sciences.
More about his work
Dr. Noemí García Ramírez
Researcher
Biology, Biological Sciences
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Dr. Marion Emilie Genevieve Brunck
Researcher
Microbiology
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Dr. Augusto Rojas Martínez
Researcher
Biomedical Sciences, Genetic Medicine and Molecular Biology
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Dr. Flavio Fernando Contreras Torres
Researcher
Physics and Chemistry
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Dr. Guillermo Torre Amione
Researcher
Biomedical sciences, cardiology and immunological medicinea
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Latest Works and Publications of the Institute
- Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis. European Journal of Heart Failure. 23:1739-1747. 2021
- Differential analysis of the bacterial community in colostrum samples from women with gestational diabetes mellitus and obesity. Scientific Reports. 11. 2021
- Dna repair genes as drug candidates for early breast cancer onset in latin america: A systematic review. International Journal of Molecular Sciences. 22. 2021
- Glucolipotoxicity-induced oxidative stress is related to mitochondrial dysfunction and apoptosis of pancreatic ß-cell. Current Diabetes Reviews. 17. 2021
- High iodine urinary concentration is associated with high tsh levels but not with nutrition status in schoolchildren of northeastern Mexico. Nutrients. 13. 2021
- Hyaluronate functionalized multi-wall carbon nanotubes loaded with carboplatin enhance cytotoxicity on human cancer cell lines. Materials. 14. 2021
- Immune cell arrival kinetics to peritoneum and role during murine-experimental trichomoniasis. Parasitology. 148:1624-1635. 2021
- Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery. Scientific Reports. 11. 2021
- Metastatic tnbc is closely associated with a fused mitochondrial morphology and a glycolytic and lipogenic metabolism. Biochemistry and Cell Biology. 99:447-456. 2021
- Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter. Frontiers in Genetics. 11. 2021
- Solvent-free functionalization of graphene oxide powder and paper with aminobenzo-crown ethers and complexation with alkali metal cations. Materials Chemistry and Physics. 260. 2021
- Synthesis and design of Ag¿Fe bimetallic nanoparticles as antimicrobial synergistic combination therapies against clinically relevant pathogens. Scientific Reports. 11. 2021